Protein Details: Gamma-aminobutyric acid receptor-associated protein

Function

Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in autophagy: while LC3s are involved in elongation of the phagophore membrane; the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264; participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress; which then fuse with lysosomes for endoplasmic reticulum turnover. Also required for the local activation of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex; regulating ubiquitination and degradation of TIAM1; a guanyl-nucleotide exchange factor (GEF) that activates RAC1 and downstream signal transduction. Thereby; regulates different biological processes including the organization of the cytoskeleton; cell migration and proliferation. Involved in apoptosis.

Sequence

PDB Structures

Ligand Binding